2-[3,5-Bis-(2-fluorobenzylidene)-4-piperidon-1-yl]-N-(4-fluorobenzyl)-acetamide and Its Evaluation as an Anticancer Agent

Figure 2

Synthesis of ¹⁸F-NFLOBA-EF24 (a) and authentic NFLOBA-EF24 (b). The reaction conditions were: (i) CF₃SO₃Me, benzene, 80°C, 1 h; (ii) [¹⁸F]F^-, K(2.2.2), K₂CO₃, DMSO, 100°C, 15 min; (iii) 1 M LiAlH₄ in THF, 80°C, 5 min; (iv) bromoacetyl bromide, DCM, RT, 2 min; (v) EF24, Cs₂CO₃, KI, DMF, 85°C, 1 h; (vi) bromoacetyl bromide, triethylamine, DCM, RT, 2 h; (vii) EF24, Cs₂CO₃, KI, DMF, 85°C, 1 h.

(a)

(b)