Synthesis and Biological Evaluation of Some Novel Dithiocarbamate Derivatives

Figure 1

(a) Ligand binding sites in acetylcholinesterase. Hydrophobic residues in the gorge are shown as orange sticks. The surface of the protein is shown in cadetblue. Acetylcholine (green sticks) is shown in the catalytic anionic site (CAS). π-Cation interactions and hydrogen bonds are shown as white dotted lines. The acyl pocket residues are shown as brown sticks. (b) Interaction between rivastigmine and acetylcholinesterase. After hydrolysis, rivastigmine, shown as coral sticks, releases the carbamate residue towards the acyl pocket and enzyme inhibition occurs. Images were taken from the official web site of European Bioinformatics Institute.

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