Synthesis and Biological Evaluation of Some Novel Dithiocarbamate Derivatives

Table 1

Some physicochemical properties of the synthesized compounds.

Comp.	X	R	Yield (%)	M.p. (°C)	M.p. (°C) [Lit.]	Molecular formula	Molecular weight (g/mol)	Appearance
1a	CH2	—	73	97	95 31]	C11H14N2O2	206	Yellow
1b	O	—	69	161	158-159 32]	C10H12N2O3	208	Yellow
1c	N–CH3	—	79	106	105-106 33]	C11H15N3O2	221	Yellow
2a	CH2	—	42	41	40 34]	C11H16N2	176	White
2b	O	—	51	131	129.5–130.5 35]	C10H14N2O	178	Brown
2c	N–CH3	—	49	92	93 36]	C11H17N3	191	White
3a	CH2	—	79	132	—	C13H17ClN2O	252.5	Brown
3b	O	—	81	171	170–172 37]	C12H15ClN2O2	254.5	Brown
3c	N–CH3	—	76	186	—	C13H18ClN3O	267.5	Brown
4a	CH2	–N(CH3)2	75	142	—	C16H23N3OS2	337	Cream-colored
4b	CH2	–N(C2H5)2	83	127	—	C18H27N3OS2	365	Brown
4c	CH2	Pyrrolidin-1-yl	85	163	—	C18H25N3OS2	363	Cream-colored
4d	CH2	Piperidin-1-yl	82	235	—	C19H27N3OS2	391	Cream-colored
4e	CH2	4-Methylpiperidin -1-yl	79	212	—	C20H29N3OS2	405	Brown
4f	CH2	4-Benzylpiperidin-1-yl	84	220	—	C26H33N3OS2	481	Brown
4g	O	–N(CH3)2	87	148	—	C15H21N3OS2	339	Brown
4h	O	–N(C2H5)2	78	97	—	C17H25N3O2S2	367	White
4i	O	Pyrrolidin-1-yl	73	175	—	C17H23N3O2S2	365	Cream-colored
4j	O	Piperidin-1-yl	77	171	—	C18H25N3O2S2	393	Brown
4k	O	4-Methylpiperidin -1-yl	69	165	—	C19H27N3O2S2	407	Cream-colored
4l	O	4-Benzylpiperidin-1-yl	72	150	—	C25H31N3O2S2	483	Cream-colored
4m	N–CH3	–N(CH3)2	70	185	—	C16H24N4OS2	352	Brown
4n	N–CH3	–N(C2H5)2	78	152	—	C18H26N4OS2	380	White
4o	N–CH3	Pyrrolidin-1-yl	73	175	—	C19H28N4OS2	378	Cream-colored
4p	N–CH3	Piperidin-1-yl	75	147	—	C20H30N4OS2	406	Brown
4r	N–CH3	4-Methylpiperidin-1yl	71	179	—	C26H34N4OS2	420	Brown
4s	N–CH3	4-Benzylpiperidin-1-yl	82	155	—	C16H24N4OS2	496	Cream-colored