Synthesis and Biological Evaluation of Some Novel Dithiocarbamate Derivatives

Table 3

Antimicrobial activities of the compounds as MIC values (μg/mL).

Comp.	A	B	C	D	E	F	G	H	I
4a	25	50	25*	25*	25*	25**	25**	25**	25**
4b	200	50	50	50	200	50*	25**	50*	50*
4c	25	50	50	50	50	50*	50*	25**	50*
4d	200	50	50	50	200	50*	50*	50*	25**
4e	50	50	25*	25*	50	25**	50*	25**	50*
4f	25	50	50	50	50	50*	50*	50*	50*
4g	200	200	200	200	200	50*	50*	50*	200
4h	50	50	50	50	200	200	100	400	400
4i	200	200	200	200	200	400	50*	400	400
4j	200	200	200	200	200	400	50*	400	400
4k	200	50	50	50	200	400	50*	400	400
4l	200	200	50	50	200	400	50*	400	200
4m	200	50	50	50	200	400	50*	50*	200
4n	200	200	50	50	50	400	50*	50*	200
4o	200	50	50	50	200	400	50*	50*	200
4p	200	200	25*	25*	200	400	50*	200	200
4r	50	50	50	50	50	400	50*	400	50*
4s	200	200	50	50	200	400	100	200	400
Ref-1	6.125	25	25	25	25	—	—	—	—
Ref-2	—	—	—	—	—	50	50	50	50

A: Enterococcus faecalis (ATCC 29212), B: Pseudomonas aeruginosa (ATCC 27853), C: Klebsiella pneumoniae (ATCC 700603), D: Escherichia coli (ATCC 35218), E: Escherichia coli (ATCC 25923), F: Candida albicans (ATCC 10231), G: Candida glabrata (ATCC 90030), H: Candida krusei (ATCC 6258), and I: Candida parapsilosis (ATCC 7330). Ref-1: chloramphenicol, Ref-2: ketoconazole. *Equal activity to reference. **Better activity than reference.