Synthesis, Crystal Structure, and Biological Activity of cis/trans Amide Rotomers of (Z)-N′-(2-Oxoindolin-3-ylidene)formohydrazide

Table 5

In vitro cytotoxic activities of the compound 2 against hepatocellular carcinoma (HepG2) and breast cancer (MCF-7) cell lines.

IC50 (M)^a
	HepG2	MCF-7
Compound 2	105	183
Doxorubicin	29.5	3.3

IC₅₀ values are the mean ± S.D. of three separate experiments.