Synthesis of Some Polysubstituted Nicotinonitriles and Derived Pyrido[2,3-d]pyrimidines as In Vitro Cytotoxic and Antimicrobial Candidates

Table 2

Minimal inhibitory concentrations (MIC; µg/mL) of the tested compounds.

Compound number	S. aureus	B. subtilis	M. luteus	E. coli	P. aeruginosa	K. pneumonia	C. albicans
3	50	50	—	25	100	—	—
4	50	100	—	50	—	—	—
5	50	100	200	100	200	—	—
13	100	100	100	50	100	—	—
15	100	200	—	100	100	200	—
18	25	100	50	25	50	100	100
19	100	100	—	50	50	—	—
20	25	100	—	25	50	200	100
21	100	100	50	100	200	50	—
22	50	100	100	50	100	50	—
23	50	100	200	100	50	100	—
29	100	100	50	50	100	200	100
30	12.5	50	50	6.25	25	100	50
31	50	100	—	12.5	200	100	50
33	6.25	25	25	6.25	12.5	50	12.5
34	12.5	25	100	6.25	25	100	25
35	25	100	200	25	50	—	100
36	12.5	50	100	12.5	25	—	25
37	25	50	50	12.5	100	—	50
Ampicillin	6.25	12.5	12.5	6.25	12.5	12.5	—
Clotrimazole	—	—	—	—	—	—	6.25

Inactive: MIC > 200 µg/mL.