Purin-6-One Derivatives as Phosphodiesterase-2 Inhibitors

Figure 3

Binding mode of compounds 2j (a), 2p (b), and 2q (c) in the active site pocket of PDE2. Each ligand is rendered as balls and sticks and the surrounding residues are rendered as sticks. For the convenience of display, some residues and atoms are not shown. See Figure 2 for the color codes of the atom types.

(a)

(b)

(c)