Synthesis and Experimental Validation of New PDI Inhibitors with Antiproliferative Activity

Table 1

Inhibition of PDI reductase activity (expressed in %) by the synthesized compounds and IC₅₀ values of the most potent ones.

Compound	PDI reductase activity inhibition (%)	IC50 (μM)
PACMA 31	80.5	10.0 ± 0.10
1	57.2
2	35.9
3	80.7	>30
4	93.3	>30
5	87.6	>30
6	64.6
7	22.6
8	98.5	1.51 ± 0.09
9	97.5	1.69 ± 0.22
10	82.3	4.17 ± 0.40

Each value represents the average of three independent experiments ± SD.