Research Article

New Caffeic Acid Phenylethyl Ester Analogs Bearing Substituted Triazole: Synthesis and Structure-Activity Relationship Study towards 5-Lipoxygenase Inhibition

Scheme 3

Synthesis of series 3: (i): 6, NaN3, MeI, CuI, acetone/H2O (1/1), rt, ultrasound, overnight (12a: 24%). (ii): NaN3, DMSO, rt, overnight; (iii): 6, CuSO45H2O, Sodium ascorbate, H2O, rt, overnight (12b: 59%; 12c: 55%; 12d: 54%; 12e: 63%; 12f: 22%; 12g: 51%).