Thiazolopyridines Improve Adipocyte Function by Inhibiting 11 Beta-HSD1 Oxoreductase Activity

Figure 1

Binding modes of native ligand and TR-04 in the X-ray crystal structure of 11β-HSD1 (PDB ID: 4K1L). (a) Superimposition of the poses of cocrystallized native ligand (shown in yellow colored tube representation) with its binding conformation (shown in maroon colored tube representation). (b) The interactions between inbound ligand and amino acid residues of binding pocket (4K1L). (c) The pose of TR-04 (shown in ball-and-stick representation). (d) The interactions between TR-04 and amino acid residues of binding pocket (4K1L). Green colored circles indicate hydrophobic amino acid residues; blue colored circles indicate polar amino acid residues.

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