Research Article

Thiazolopyridines Improve Adipocyte Function by Inhibiting 11 Beta-HSD1 Oxoreductase Activity

Figure 4

Tetrahydrothiazolopyridine derivatives TR-01–4 inhibited 11β-HSD1 oxoreductase activity in the mature 3T3-L1 adipocytes. Cells were treated for 2 h with 0–100 μM of the test compounds and incubated in DMEM containing cortisone (1 μM) for 20 min. The resulting metabolite/conversion ratios were measured by LC-MS. Data are the mean ± SEM (). versus vehicle by Dunnett’s test subsequent to one-way ANOVA.
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