Research Article

Thiazolopyridines Improve Adipocyte Function by Inhibiting 11 Beta-HSD1 Oxoreductase Activity

Figure 6

Effect of tetrahydrothiazolopyridine derivative TR-04 on the expression levels of adipocyte genes associated with lipid metabolism and insulin resistance. Adipocytes were differentiated in the presence of 1 μM cortisone and 100 nM of TR-04 and extracted with TRIzol for mRNA measurements by qPCR. Data are the mean ± SEM (), normalized with respect to the expression of the β-actin of undifferentiated control cells. and versus vehicle control by two-tailed Student’s -test.