1-(2-Chlorobenzyloxy)-3-[1,2,3]triazol-1-yl-propan-2-ol Derivatives: Synthesis, Characterization, and DFT-Based Descriptors Analysis

Table 1

Effect of catalyst, reducing agent, base, and solvent.

Entry	Copper salt	Reducing agent	Base	Solvent	% yield
7	CuSO4	Glucose	NaOH	MeOH-H2O	34
8	CuSO4	Sodium ascorbate	none	tBuOH-H2O	28
9	CuI	None	NaOH	MeOH-H2O	40
10	CuI	None	DIPEA	MeOH	35
11	CuI	None	DIPEA	CH2Cl2	85