A Stability-Indicating RP-HPLC-UV Method for Determination and Chemical Hydrolysis Study of a Novel Naproxen Prodrug

Table 2

Results of forced degradation stability studies.

Stress condition	Nature of pro-NP	Number of determinations	Time (hours)	Temperature (°C)	Degradation (%)
Hydrolysis, acidic	Solution	In 0.1 N HCl	24	25	21.5
Hydrolysis, alkali	Solution	In 0.1 N NaOH	0	25	100
		In 0.01 N NaOH	0	25	100
Oxidation	Solution	In 3% H2O2	24	25	0
		In 3% H2O2	24	50	0
		In 6% H2O2	2	50	0
Thermal	Solid	Once	48	70	0
Photolytic	Solid	Once	48	25	0