Hantzsch Reaction Starting Directly from Alcohols through a Tandem Oxidation Process

Table 1

Model of Hantzsch reaction directly from benzyl alcohol in different ionic liquids.

Entry	Ionic liquid	Ratio	Yield (%)
1	[DDPA][HSO4]	3a : 4a = 93 : 7	91
2	[Hmim][H2PO4]	3a : 4a = 86 : 14	37
3	[Hmim]NO3	—	—
4	[bmin]BF4	—	—

Benzyl alcohol (3 mmol), ethyl acetoacetate (3 mmol), ammonium acetate (3 mmol), ionic liquid (1.2 mmol), and NaNO₃ (6 mmol), 1 h. Yields and ratios were based on GC analysis. Yields referred to the desired product 3a.