Preparation and Optimization of 10-Hydroxycamptothecin Nanocolloidal Particles Using Antisolvent Method Combined with High Pressure Homogenization

Table 2

The factors of orthogonal and experimental result.

Volume ratio of DMSO and H2O	Dripping speed (mL/min)	MPS (nm)	Yield (%)
1 : 1	1	1284.8	82.8
	2	991.6	82.6
	3	1123.4	80.8
	4	896.4	84.6
	5	1077	83.0
1 : 3	1	1243.1	72.2
	2	1005.6	77.2
	3	1082.8	74.4
	4	1044.1	77.0
	5	1175.2	73.0
1 : 5	1	1275.7	72.4
	2	820.6	76.6
	3	961.9	73.8
	4	1079.5	76.2
	5	1011.9	71.2