Synthesis of Novel 1,2,4-Triazolyl Coumarin Derivatives as Potential Anticancer Agents

Table 2

Cytotoxic activity of compounds 4a–c, 5a–c, and 8a–c against the human colorectal cancer cell line (HCT116).

Comp. no.	IC50 (µM)	Relative potency
4a	13.865	18.76%
4b	44.704	5.82%
4c	4.363	59.62%
5a	129.259	2.01%
5b	266.089	0.98%
5c	39.133	6.65%
8a	25.630	10.15%
8b	15.296	17.00%
8c	2.656	97.93%
Doxorubicin	2.601	100%

Compared to doxorubicin.