Design, Synthesis, Antihyperglycemic Studies, and Docking Simulations of Benzimidazole-Thiazolidinedione Hybrids

Table 1

Molecular docking binding energies, calculated affinities, and qualitative pharmacological activities of compounds 1–3.

Compound	PPARγ ΔG (kcal/mol)	Ki (μM)	In vitro activity	In vivo effect
1	−7.98	1.346	++	++
2	−8.17	0.976	+++	+++
3	−8.96	0.256	+++	+++
p-Coumaric acid	−4.64	385.9	+ [8]	+ [8]
Rivoglitazone	−7.33	4.261	++ [6]	++ [18]

References [6], [8], and [18].