Kinase Inhibitors of Novel Pyridopyrimidinone Candidates: Synthesis and In Vitro Anticancer Properties

Figure 5

The interaction between compound 6 and CDK6 kinase protein (PDB code: 5L2I), presented by MOE 2015: (a, b) 3D compound 6 binding geometry (yellow sticks) in the CDK6 binding site cavity. (c) 2D interaction diagram of compound 6 with the CDK6 binding site cavity. (d) 2D diagrams of compound 6 (green) and padlbocyclib (red) were overlapping.