Kinase Inhibitors of Novel Pyridopyrimidinone Candidates: Synthesis and In Vitro Anticancer Properties

Table 1

Percentage of kinase inhibition of derivative 6 at 100 μM.

Kinase	Compound 6
	% Inhibition
AKT1	−79
AKT2	−85
BRAF (V600E)	−91
CDK2/cyclin A1	−78
CHK1	−6
EGFR	−97
PDGFRβ	−94
c-RAF	37