The Design, Synthesis, and Characterization of Resveratrol Derivatives Modified by Different γ-Aminobutyric Acid Esters

Table 1

Log P_ow, water solubility, and topological PSA values of resveratrol and corresponding derivatives.

Compound	Log Pow	PSA (Å^2)	Solubility (g/L)
Resveratrol	2.57	60.68	0.03
GABA	−2.99	63.32	1.73
2a	−1.07	52.33	0.49
2b	1.44	110.46	0.03
2c	3.22	193.91	0.0033
3a	−0.46	52.33	0.66
3b	1.86	110.46	0.02
3c	4.36	193.91	0.0025
4a	0.02	52.33	1.03
4b	2.23	110.46	0.01
4c	5.03	193.19	0.0018