One-Pot Synthesis of Novel Furochromone and Oxazocine Derivatives as Promising Antitumor Agents with Their Molecular Docking Studies

Table 1

The antiproliferative potency of the newly prepared derivatives toward hepatic and breast cancer cell lines.

Compound	Cell lines
	MCF-7 IC50 ± SD (μg/mL)	HEPG-2 IC50 ± SD (μg/mL)
Solvent (DMSO)	76 ± 0.66	77 ± 0.53
1	53 ± 0.35	44 ± 5.43
4a	43 ± 0.20	35 ± 0.12
4b	37 ± 1.17	43 ± 2.90
4c	55 ± 0.58	51 ± 0.37
4d	45 ± 1.04	49 ± 1.10
4e	41 ± 11.28	33 ± 2.10
4f	50 ± 2.79	64 ± 3.10
4g	52 ± 1.52	45 ± 0.47
4h	43 ± 1.15	55 ± 1.33
5a	23 ± 1.03	47 ± 2.80
5b	20 ± 1.44	33 ± 2.33
5c	19 ± 1.22	43 ± 1.57
5d	25 ± 2.67	32 ± 1.67
5e	18 ± 1.73	54 ± 1.27
5f	24 ± 0.10	45 ± 0.09
5g	26 ± 3.23	56 ± 2.59
5h	19 ± 1.19	41 ± 1.39
6	44 ± 1.86	56 ± 1.79
7a	34 ± 1.34	45 ± 1.64
7b	33 ± 2.79	39 ± 0.47
5 fluorouracil	13 ± 0.56
Doxorubicin		14 ± 1.07