Synthesis, Biological Activity, and Molecular Modeling Studies of Pyrazole and Triazole Derivatives as Selective COX-2 Inhibitors

Figure 2

Predicted binding orientations of (a) 4a, (b) 4b, (c) 4c, (d) 4d, (e) 4e, (f) 4f, (g) 4g, (h) 8a, (i) 8b, (j) 15a, and (k) 15b visualized in COX-1 active site (PDB code 3KK6 [31]); ligands are shown in orange and amino acids are shown in blue. Only the interacting residues and their interaction patterns are shown.

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