Synthesis, Biological Activity, and Molecular Modeling Studies of Pyrazole and Triazole Derivatives as Selective COX-2 Inhibitors

Scheme 2

Synthesis of triazole derivatives (8a and 8b). Reagents and conditions: (a) HCl, NaNO₂, and NaN₃; (b) 4-ethynyl-α,α,α-trifluorotoluene 7, CuSO₄, sodium ascorbate, and DCM : H₂O (1 : 1).