Synthesis, Biological Activity, and Molecular Modeling Studies of Pyrazole and Triazole Derivatives as Selective COX-2 Inhibitors

Table 1

In vitro activity on COX-1 and COX-2 with selectivity index.

Compound	IC50 COX-1 (μM)	IC50 COX-2 (μM)	Selectivity index
4a	17.507 ± 1.050	1.386 ± 0.083	12.631
4b	0.263 ± 0.016	0.017 ± 0.001	15.471
4c	18.646 ± 1.119	1.305 ± 0.078	14.288
4d	5.375 ± 0.323	0.098 ± 0.006	54.847
4e	21.306 ± 1.278	0.551 ± 0.033	38.668
4f	3.438 ± 0.206	1.902 ± 0.114	1.902
4g	0.012 ± 0.001	1.460 ± 0.088	0.008
8a	0.145 ± 0.009	3.324 ± 0.199	0.044
8b	0.075 ± 0.005	0.226 ± 0.014	0.332
15a	0.325 ± 0.020	0.002 ± 0.000	162.500
15b	0.273 ± 0.016	0.131 ± 0.008	2.084
Celecoxib	1.479 ± 0.089	0.004 ± 0.000	369.750