Coumarins and Polar Constituents from Eupatorium triplinerve and Evaluation of Their α-Glucosidase Inhibitory Activity

Table 1

α-glucosidase inhibitory activity of compounds 4–9 and 11.

Compound	α-glucosidase inhibitory activity (%)					IC50 (μg/mL) (μM)
	256 μg/mL	64 μg/mL	16 μg/mL	4 μg/mL	1 μg/mL
4	40	38	35	30	25	>256
5	46	41	38	30	19	>256
6	2	0	0	0	0	>256
7	81	53.5	22	16	0	58.65 ± 1.20 (302)
8	2	0	0	0	0	>256
8/9	2	0	0	0	0	>256
11	2	0	0	0	0	>256
Acarbose: IC50 197.33 ± 2.51 μg/mL [306 μM]

¹H-NMR: molar ratio 1 : 1.