Facile Synthesis of Propranolol and Novel Derivatives

Figure 3

The scheme describes the synthesis of propranolol with (i) 2-chlorobenzoyl chloride; (ii) 2-bromobenzoyl chloride; (iii) 2-flourobenzoyl chloride, at conditions of CHCl₃ and NaHCO₃ at 50°C for 24 h.