Facile Synthesis of Propranolol and Novel Derivatives

Table 1

Summary of propranolol derivatives.

2-((Naphthalen-1-yloxy)methyl)oxirane	Propranolol
2-Chloro-3-(naphthalen-1-yloxy)propan-1-ol	1-Chloro-3-(naphthalen-1-yloxy)propan-2-ol
2-Chloro-N-(2-hydroxy-3-(naphthalen-1-yloxy)propyl)-N-isopropylbenzamide	1-(Isopropylamino)-3-(naphthalen-1-yloxy)propan-2-yl 2-chlorobenzoate
2-Bromo-N-(2-hydroxy-3-(naphthalen-1-yloxy)propyl)-N-isopropylbenzamide	1-(Isopropylamino)-3-(naphthalen-1-yloxy)propan-2-yl 2-bromobenzoate
2-Flouro-N-(2-hydroxy-3-(naphthalen-1-yloxy)propyl)-N-isopropylbenzamide	1-(Isopropylamino)-3-(naphthalen-1-yloxy)propan-2-yl 2-fluorobenzoate
N-(2-Hydroxy-3-(naphthalen-1-yloxy)propyl)-N-isopropylacetamide	1-(Isopropylamino)-3-(naphthalen-1-yloxy)propan-2-yl acetate
1-(Isopropylamino)-3-(naphthalen-1-yloxy)propan-2-one hydrate	1-(Butyl(isopropyl)amino)-3-(naphthalen-1-yloxy)propan-2-ol