New Benzoxazole Derivatives as Antiprotozoal Agents: In Silico Studies, Synthesis, and Biological Evaluation

Scheme 1

Synthetic pathway of 2a–g and 4a–d. Conditions and reagents: (1) ArCHO, CH₃CH₂ OH, CH₃COOH, reflux, 4 h; (2) cyanuric chloride, acetone, rt, 1 h; and (3) aryl amine, K₂CO₃, dioxane, reflux, 12 h.