Research Article
New Benzoxazole Derivatives as Antiprotozoal Agents: In Silico Studies, Synthesis, and Biological Evaluation
Table 2
Antileishmanial and antitrypanosomal activity of compounds 5-6.
| | Comp. | L. donovani promastigote | L. donovani amastigote | L. donovani Amastigote + THP | T. brucei | THP | | aIC50 | bIC90 | IC50 | IC90 | IC50 | IC90 | IC50 | IC90 | IC50 | IC90 |
| | 5a | 15.1 | — | 28.3 | 32.6 | 6.04 | 10.4 | 5.38 | 6.43 | 11.3 | 24.0 | | 6a | — | — | — | — | — | — | 16.8 | 24.1 | 5.02 | — | | 6c | — | — | — | — | — | — | 15.7 | 24.5 | — | — | | 6d | 23.7 | — | 17.9 | 25.6 | 20.6 | — | 2.75 | 3.81 | — | — | | Amb | 0.178 | 0.229 | 0.333 | 0.390 | 0.159 | 0.230 | NT | NT | — | — | | Pm | 4.88 | 7.62 | 29.2 | — | 3.08 | 17.3 | NT | NT | — | — | | DFMO | NT | NT | NT | NT | NT | NT | 21.7 | 50.3 | NT | NT |
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aIC50: concentration causing 50% growth inhibition; bIC90: concentration causing 90% growth inhibition; Amb = amphotericin B; Pm = pentamidine; DFMO = difluoromethylornithine.
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