Journal of Chemistry

Research Article

Synthesis, Molecular Docking, MEP and SAR Analysis, ADME-Tox Predictions, and Antimicrobial Evaluation of Novel Mono- and Tetra-Alkylated Pyrazole and Triazole Ligands

Table 1

Antibacterial activity of the newly synthesized mono- and tetra-alkylated pyrazole and triazole derivatives determined by the broth macrodilution assay and using the phenol red indicator.
EntryL. monocytogenesE. coliS. aureusC. freundii
1− − −− − −− − −− − −
2− − −− − −− − −− − −
3− − −− − −− − −− − −
4− − −− − −− − −− − −
5− − −− − −− − −− − −
6− − −− − −− − −− − −
7− − −− − −− − −− − −
8− − −− − −− − −− − −
9− − −− − −− − −− − −
10− − −− − −− − −− − −
11− − −− − −− − −− − −
12+ + ++ + ++ + ++ + +
13+ + ++ + ++ + ++ + +