Rational Design, Synthesis, In Vitro, and In Silico Studies of Dihydropyrimidinone Derivatives as β-Glucuronidase Inhibitors

Table 1

β-glucuronidase inhibitory activity of the dihydropyrimidinone derivatives.

Compound	R	IC50 (μM ± SE)^a
4a		>100
4b		87.25 ± 4.13
4c		42.19 ± 3.27
4d		52.48 ± 4.81
4e		91.27 ± 4.67
4f		>100
4g		73.12 ± 2.69
4h		46.33 ± 4.13
4i		31.52 ± 2.54
D-saccharic acid 1,4-lactone ^b		41.32 ± 1.82

^a IC₅₀ values are expressed as mean ± standard error of the mean. ^b Standard inhibitor for β-glucuronidase.