Synthesis of 4,7,9-Trihydroxy[1]benzofuro[3,2-d]pyrimidine-6-carboxamide: Evaluation of Cytotoxicity and Inhibition of Protein Kinase C (CaPkc1)

<div>(a) NIS, CH2Cl2, −78°C, 2 min, 71%. (b) NaH 60%, DMF, ethyl bromoacetate, rt, 12 h, 72%. (c) CuCN, DMF, 160°C, 2 h, 75%. (d) NaH 60%, DMF, 0°C, 30 min, 51%. (e) (1) HC (OEt)3, MW, 200°C, 15 min, (2) NH3/MeOH 7N, MW, 140°C, 15 min, 46%. (f) H2O2 35%, K2CO3, rt, 24 h or NaOH/EtOH 6N, H2O2 35%, rt, 24 h or urea-hydrogen peroxide, K2CO3, acetone/H2O, rt, 5 h or BF3.2CH3COOH or H2SO4 cc, 15 min, failure.</div>

Journal of Chemistry

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Figure 2

Figure 2: Synthesis of 4,7,9-Trihydroxy[1]benzofuro[3,2-d]pyrimidine-6-carboxamide: Evaluation of Cytotoxicity and Inhibition of Protein Kinase C (CaPkc1)

Figure 2 | Synthesis of 4,7,9-Trihydroxy[1]benzofuro[3,2-d]pyrimidine-6-carboxamide: Evaluation of Cytotoxicity and Inhibition of Protein Kinase C (CaPkc1) 