Synthesis of 4,7,9-Trihydroxy[1]benzofuro[3,2-d]pyrimidine-6-carboxamide: Evaluation of Cytotoxicity and Inhibition of Protein Kinase C (<i>Ca</i>Pkc1)

<div>(a) CSI, CH<sub>3</sub>CN, 0°C, 10 min and then HCl 5 M, rt, 10 h, 45%. (b) NIS, CH<sub>2</sub>Cl<sub>2</sub>, 0°C, 10 min, 60%. (c) CuCN, DMF, 160°C, 6 h, 38%. (d) NaH, BrCH<sub>2</sub>CO<sub>2</sub>Et, DMF, rt, 24 h, 90%. (e) NaH, DMF, 0°C, 10 min, 67%. (f) HC (OEt)<sub>3</sub>, MW, 200°C, 15 min and then NH<sub>3</sub>/MeOH 7N, MW, 140°C, 15 min, 62%. (g) Pyridine. HCl, MW, 200°C, 10 min, 43%.</div>

Journal of Chemistry

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Figure 3

Figure 3: Synthesis of 4,7,9-Trihydroxy[1]benzofuro[3,2-d]pyrimidine-6-carboxamide: Evaluation of Cytotoxicity and Inhibition of Protein Kinase C (<i>Ca</i>Pkc1) 

Figure 3 | Synthesis of 4,7,9-Trihydroxy[1]benzofuro[3,2-d]pyrimidine-6-carboxamide: Evaluation of Cytotoxicity and Inhibition of Protein Kinase C (CaPkc1) 