Synthesis of 4,7,9-Trihydroxy[1]benzofuro[3,2-d]pyrimidine-6-carboxamide: Evaluation of Cytotoxicity and Inhibition of Protein Kinase C (CaPkc1)

Table 1

Activity of compound 13 on protein extract of CAAL93 and HeLa.

Compounds	Structure	MIC values (µM)^a
		HeLa	Protein extract of CAAL93
13		227.53 ± 27.97	87 ± 2%
CERCO^b		<3	53 ± 3%

^aValues represent the mean ± SD of experiments performed in triplicate. MIC was determined as the compound concentration that produced 50% of growth inhibition relative to that of the drug-free growth control. ^bCERCO, (–)-cercosporamide.