Synthesis, In Silico, and Biological Applications of Novel Heteroleptic Copper (II) Complex of Natural Product-Based Semicarbazone Ligands

Table 2

Antibacterial activity results of the compounds.

Compounds	Conc. (µg/mL)	Gram-negative		Gram-positive
		E. coli	P. aeruginosa	S. aureus	S. pyogenes
L1	100	8.00 ± 0.21	7.35 ± 0.42	10.52 ± 0.22	9.23 ± 0.46
	200	9.40 ± 0.42	8.33 ± 0.37	12.42 ± 0.23	11.64 ± 0.12
L2	100	4.50 ± 0.24	3.50 ± 0.00	6.34 ± 0.42	6.64 ± 0.47
	200	5.44 ± 0.54	7.33 ± 0.46	8.68 ± 0.32	8.84 ± 0.32
[Cu(L1) (L2)]	100	9.20 ± 0.44	10.46 ± 0.44	11.67 ± 0.25	12.44 ± 0.22
	200	11.12 ± 0.54	12.43 ± 0.23	12.62 ± 0.34	13.67 ± 0.52
Trimethoprim (standard drug)	100	14.69 ± 0.47	16.64 ± 0.48	14.05 ± 0.44	16.71 ± 0.26

Note:-mean ± SD of triplicates is measured in mm, where SD = standard deviation.