Research Article
3,5-Dinitrobenzoate and 3,5-Dinitrobenzamide Derivatives: Mechanistic, Antifungal, and In Silico Studies
Table 1
Minimal inhibitory and fungicidal concentrations (MFC/MIC) of 3,5-dinitrobenzoic acid and its derivatives expressed in µg/mL and mM.
| | Compounds | Candida albicans (CBS 562) | Candida krusei (CBS 573) | Candida tropicalis (CBS 94) | | MIC (µg/mL)/(mM) | MFC (µg/mL)/(mM) | MFC/MIC | MIC(µg/mL)/(mM) | MFC(µg/mL)/(mM) | MFC/MIC | MIC(µg/mL)/(mM) | MFC(µg/mL)/(mM) | MFC/MIC |
| | 1 | 1000/4.71 | 1000/4.71 | 1 | 1000/4.71 | 1000/4.71 | 1 | 1000/4.71 | 1000/4.71 | 1 | | 2 | 125/0.52 | 250/1.04 | 2 | 1000/4.16 | 1000/4.16 | 1 | 500/2.08 | 500/2.08 | 1 | | 3 | 250/0.98 | 500/1.96 | 2 | 1000/3.92 | 1000/3.92 | 1 | 500/1.96 | 500/1.96 | 1 | | 4 | >1000/3.92 | >1000/3.92 | | 1000/3.92 | 1000/3.92 | 1 | >1000/3.92 | >1000/3.92 | | | 5 | 1000/3.73 | 1000/3.73 | 1 | 1000/3.73 | 1000/3.73 | 1 | >1000/3.73 | >1000/3.73 | | | 6 | 1000/3.54 | 1000/3.54 | 1 | >1000/3.54 | >1000/3.54 | | >1000/3.54 | >1000/3.54 | | | 7 | >1000/3.54 | >1000/3.54 | | >1000/3.54 | >1000/3.54 | | >1000/3.54 | >1000/3.54 | | | 8 | 1000/2.83 | 1000/2.83 | 1 | >1000/2.83 | >1000/2.83 | | >1000/2.83 | >1000/2.83 | | | 9 | 1000/2.97 | 1000/2.97 | 1 | 250/0.74 | 250/0.74 | 1 | 1000/2.97 | 1000/2.97 | 1 | | 10 | >1000/3.30 | >1000/3.30 | | >1000/3.30 | >1000/3.30 | | >1000/3.30 | >1000/3.30 | | | 11 | >1000/3.01 | >1000/3.01 | | 1000/3.01 | 1000/3.01 | 1 | >1000/3.01 | >1000/3.01 | | | 12 | >1000/2.90 | >1000/2.90 | | 1000/2.90 | 1000/2.90 | 1 | >1000/2.90 | >1000/2.90 | | | 13 | >1000/2.88 | >1000/2.88 | | >1000/2.88 | >1000/2.88 | | >1000/2.88 | >1000/2.88 | | | 14 | >1000/3.01 | >1000/3.01 | | >1000/3.01 | >1000/3.01 | | >1000/3.01 | >1000/3.01 | | | 15 | >1000/3.32 | >1000/3.32 | | >1000/3.32 | >1000/3.32 | | >1000/3.32 | >1000/3.32 | | | 16 | 1000/3.74 | 1000/3.74 | 1 | 1000/3.74 | 1000/3.74 | 1 | 1000/3.74 | 1000/3.74 | 1 | | 17 | >1000/3.48 | >1000/3.48 | | >1000/3.48 | >1000/3.48 | | >1000/3.48 | >1000/3.48 | | | 18 | >1000/2.98 | >1000/2.98 | | >1000/2.98 | >1000/2.98 | | >1000/2.98 | >1000/2.98 | | | 19 | >1000/3.13 | >1000/3.13 | | >1000/3.13 | >1000/3.13 | | >1000/3.13 | >1000/3.13 | | | 20 | >1000/3.41 | >1000/3.41 | | >1000/3.41 | >1000/3.41 | | >1000/3.41 | >1000/3.41 | | | 21 | >1000/3.02 | >1000/3.02 | | >1000/3.02 | >1000/3.02 | | >1000/3.02 | >1000/3.02 | | | Nystatin | 3.75/0.0040 | 3.75/0.0040 | 1 | 3.75/0.0040 | 3.75/0.0040 | 1 | 3.75/0.0040 | 3.75/0.0040 | 1 | | Control medium | − | | | − | | | − | | | | Fungal growth control | + | | | + | | | + | | | | 5% DMSO solution | + | | | + | | | + | | |
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(+) indicates growth of the microorganism. (−): no growth of the microorganism.
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