Design, Synthesis, and Biological Evaluation of Novel Pyrrolo [2,3-b] Pyridine Derivatives for Nonalcoholic Fatty Liver Disease

Scheme 1

Synthetic route of F series. a: LDA, THF, 0°C, 24 h.·b: CH₃I, NaH, DMF, rt,24 h. c: POCl₃, DMF, 0°C,24 h.·d: hexahydro pyridine, malonic acid, Py, refluxed, 4 h. e: EDCI, HOBT, triethylamine, rt, 0.5 h.