Synthesis and Antitumor Activity of a GSH Inert Bisphosphonate Platinum (II) Complex

Table 3

Cellular uptake of DBPP in U2OS after 24, 48, and 72 h of incubation^a.

Concentration (μM)	Pt content (μg/10^6 cells)
	24 h	48 h	72 h
50.0	0.6 ± 0.5	0.8 ± 0.9	1.3 ± 0.9
100.0	1.4 ± 0.5	3.7 ± 0.5	5.0 ± 0.3

^aTreating U2OS cells with cisplatin (10.0 μM) for 24 h resulted in 2.6 ± 0.2 μg/10⁶ cells concentration of cellular platinum.