Bioprospecting of an Endolichenic Fungus Phanerochaete sordida Isolated from Mangrove-Associated Lichen Bactrospora myriadea

Table 5

Drug likeliness, physicochemical, and pharmacokinetic properties of compound 1.

Physicochemical properties	Pharmacokinetic properties	Drug likeliness
Molecular weight g/Mol; 278.34	Gastro-intestinal (GI) absorption; High	Lipinski—yes (0 violations)
Heavy atoms; 20	Blood brain barrier (BBB) permeant; Yes	Ghose—yes
Aromatic heavy atoms; 6	P-gp substrate; No	Veber—yes
H bond donar; 2	CYP1A2 inhibitor; No	Egan—yes
H bond acceptors; 4	CYP2C19 inhibitor; No	Muegge—yes
Fraction Csp3; 0.56	CYP2C9 inhibitor; Yes	Bioavailability score—0.55
Number of rotatable bonds; 0	CYP2D6 inhibitor; No
Molar refractivity; 78.27	CYP3A4 inhibitor; No
TPSA (topological polar surface area); 66.76 Å	Log (skin permeation); -4.48 cm/s
Consensus log; 3.35