Acefylline Derivatives as a New Class of Anticancer Agents: Synthesis, Molecular Docking, and Anticancer, Hemolytic, and Thrombolytic Activities of Acefylline-Triazole Hybrids

Table 1

Biological activities of 9a–9e along with that for 2, solvent, and ABTS.

Compounds	R	Cell viability	Hemolysis (%)	Thrombolysis (%)
9a	pH	53.85 ± 3.30	4.70	39.0
9b	2-FC6H4	47.66 ± 3.59	1.86	48.0
9c	2-MeOC6H4	53.49 ± 1.97	2.87	49.4
9d	2-ClC6H4	57.63 ± 3.65	0.23	37.0
9e	4-ClC6H4	22.55 ± 0.95	1.20	26.0
Acefylline (2)		79.00 ± 2.54	43.5	6.85
DMSO		100 ± 0	0.01	0.57
ABTS		—	95.50	88.0

Note. Cell viability (Mean ± SD), (triplicate, 100 µg/mL).