IL-2 Flexible Loops Might Play a Role in IL-2 Interaction with the High-Affinity IL-2 Receptor: A Molecular Dynamics (MD) Study

Figure 3

Alignment of 100 ns frames of WT IL-2 (ruby), IL-2m (forest), and IL-2m2 (deep purple). The small boxes showed the possible hinder of F42 and L72 in WT IL-2 (ruby) that was removed by F42A and L72G mutation in IL-2m (forest). For IL-2m2, Y42 and R72 might not cause the hinder since loops rigidity that was observed in IL-2m and IL-2m2.