Development and Validation of an Ion-Pair HPLC-UV Method for the Quantitation of Quinoline and Indoloquinoline Alkaloids in Herbal and Pharmaceutical Antimalarial Formulations

Figure 2

Results for linearity and stability studies in the method validation. (a) Linearity responses for quinine over the concentration range 50–1000 μg/mL. (b) Linearity responses for all other analytes each at concentration range 10–200 μg/mL. (c) Stability of analyte solution studies. The red horizontal line indicates the lowest permissible content of analytes (90% of starting concentrations). The stability of the analyte solutions ranged between 6 and 12 hours after sample preparation.

(a)

(b)

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