High-Dose or Low-Dose Aspirin Application in the Initial Phase of Kawasaki Disease: A Meta-Analysis and Systematic Review

Table 1

Characteristics of the enrolled studies.

Author	Year	Nation	Study type	Patients number	Age, month, mean (SD)	Gender (male%)	CAA criteria	IVIG dose	NOS score	Interventions
Platt et al.	2019	USA	RCS	260	H: 32.4 (20.4–50.4)	H: 118 (64.4%)	—	2 g/kg	8	H: 75.5 mg/kg/day
					L: 28.8 (18–52.8)	L: 142 (57%)				L: 4.4 mg/kg/day
Dhanrajani et al.	2018	Canada	RCS	249	H: 36 (18–64)	H: 127 (58.3%)	—	2 g/kg	7	H: 80–100 mg/kg/day
					L: 36 (17–56)	L: 122 (59%)				L: 3–5 mg/kg/day
Huang et al.	2017	China	RCS	910	H: 25.8 (19.4)	H: 86 (69%)	Japanese criteria	2 g/kg	8	H: 30–50 mg/kg/day
					L: 23.7 (11.3)	L: 672 (63%)				L: 3–5 mg/kg/day
Dallaire et al.	2017	Canada	RCS	1213	H: 40.8 (28.8)	H: 848 (59.4%)	Z score	2 g/kg	8	H: 80 mg/kg/day
					L: 38.4 (26.4)	L:365 (58.4%)				L: 3–5 mg/kg/day
Kim et al.	2016	South Korea	RCS	8456	H: 32.6 (23.8)	H:7947 (58.3%)	Z score	2 g/kg	8	H: >30 mg/kg/day
					L: 30.8 (23.5)	L:509 (57.4%)				L: 3-5 mg/kg/day
Kuo et al.	2015	Taiwan, China	RCS	851	H: 28.8 (28.8)	H:305 (65.9%)	Japanese criteria	2 g/kg	6	H: >30 mg/kg/day
					L: 34.8 (26.4)	L:546 (61.9%)				L: 3–5 mg/kg/day
Rahbarimanesh et al.	2014	Iran	RCS	69	—	—	—	2 g/kg	4	H: 80–100 mg/kg/day
										L: 3–5 mg/kg/day
Lee et al.	2012	South Korea	RCS	180	H: 30.2 (22.3)	H:129 (55.8%)	Japanese criteria	2 g/kg	7	H: 80–100 mg/kg/day
					L: 30.7 (25.1)	L:51 (58.5%)				L: 3–5 mg/kg/day
Saulsbury	2002	USA	RCS	70	—	—	—	2 g/kg	7	H: 80–100 mg/kg/day
										L: 3–5 mg/kg/day

Note. Studies only provided with medium (IQR) value.