Copper-Catalyzed Hydroboration of Enamides with Bis(pinacolato)diboron: Promising Agents with Antimicrobial Activities

Table 2

Effect of the solvent on the hydroboration reaction^a.

MeOH	Solvent (1 ml)	t	Conv (%)	Ed^c (%)	Yield^b (%)
—	MeOH	15 min	100	48	100
—	EtOH	15 min	100	46	100
—	i-PrOH	15 min	100	32	100
2 equ	Et2O	2 h	100	44	100
2 equ	THF	30 min	100	42	100
2 equ	Toluene	12 h	50	34	35
2 equ	CH2Cl2	2 h	100	22	100

^aReaction conditions: NHCCuCl (1) (10 mol%), Cs₂CO₃ (0.1 equiv), MeOH (1 ml), and r.t. ^b isolated yield. ^cThe Ed (%) was determined by ¹H NMR analysis.