Copper-Catalyzed Hydroboration of Enamides with Bis(pinacolato)diboron: Promising Agents with Antimicrobial Activities

Table 3

The effect of catalyst on the hydroboration reaction^a.

Cat. (10 mol%)	T	t	Conv (%)	Ed^c (%)	Yield^b (%)
NHCCuCl (1)	t.a	15 min	100	48	100
NHCCuCl (2)	t.a	15 min	100	44	100
[(SIPr)CuCl]	t.a	2 h	50	54	100
[(SIMes)CuCl]	t.a	2 h	50	58	100

^aReaction conditions: 5 (0.2 mmol), B₂(pin)₂ (1.5equiv) MeOH (1 mL), Cs₂CO₃ (0.1equi), and r.t. ^bisolated yield. ^cThe Ed (%) was determined by ¹H NMR analysis.