Copper-Catalyzed Hydroboration of Enamides with Bis(pinacolato)diboron: Promising Agents with Antimicrobial Activities

Table 4

Effect of the catalytic charge on the hydroboration reaction^a.

[(SIMes)CuCl] (mol%)	T	T	Conv (%)	Ed^c (%)	Yield^b (%)
10	t.a.	2 h	100	58	100
5	t.a.	2 h	100	36	100
1	t.a.	2 h	100	38	100
0, 1	t.a.	2 h	100	38	100
0	t.a.	2 h	<5	ND

^aReaction conditions: 5 (0.2 mmol), B₂(pin)₂ (1.5 equiv) MeOH (1 mL), Cs₂CO₃ (0.1 equiv), and r.t. ^bisolated yield. ^cThe Ed (%) was determined by ¹H NMR analysis.