In Vitro and In Silico Analysis of Bergenia ciliata and Mimosa pudica for Inhibition of α-Amylase

Table 4

Pharmacokinetic analysis of compounds isolated from B. ciliata and M. pudica.

Compounds	Human intestinal absorption (HIA)%	BBB permeability (logBB)	CYP3A4 substrate inhibition	AMES toxicity	Hepato toxicity	Toxicity class	LD50 mg/kg
Gallic acid	43.374	−1.102	No	No	No	4	2000
β-sitosterol	94.464	0.781	No	No	No	4	1185
Bergenin	63.774	−1.091	No	No	No	6	10000
Gallicin	76.635	−1.046	No	Yes	No	4	1700
Catechin	68.829	−1.054	No	No	No	6	10000
Tannic acid	0	−8.62	Yes	No	No	5	2260
Galloylepicatechin	62.096	−1.847	No	No	No	4	1000
Galloylcatechin	62.096	−1.847	No	No	No	4	1000
Stigmasterol	94.97	0.771	No	No	No	4	890
Mimosine	45.69	−0.742	No	No	No	4	2000
Betulinic acid	99.763	−0.322	No	No	Yes	5	2610
Mimopudine	50.165	−1.656	No	No	Yes	4	780
Quercetin	77.207	−1.098	No	No	No	3	159
Avicularin	57.226	−1.571	No	No	No	5	5000
Allantoin	51.948	−0.566	No	No	No	5	2600
p-Coumaric acid	93.494	−0.225	No	No	No	5	2850
2-hydroxymethyl-chroman-4-one	89.486	−0.149	No	No	No	5	2647