In Silico Study of Alkaloids: Neferine and Berbamine Potentially Inhibit the SARS-CoV-2 RNA-Dependent RNA Polymerase

Table 3

The SwissADME analysis of oxysophorodine, berbamine, neferine, 10′-hydroxyusambarensine, strychnopentamine, and remdesivir (standard ligand).

S. N	Alkaloids	PubChem ID	Molecular Mass (Da)	Hydrogen bond donor (HBD <5)	Hydrogen bond acceptor (HBA <10)	Log	Molar refractivity (40–130)	Drug likeness >0
1.	Oxysophoridine	114850	278.39	0	2	1.22	87.80	0.55
2.	Berbamine	275182	608.72	1	8	5.15	181.60	0.55
3.	Neferine	159654	624.77	1	8	5.47	188.02	0.55
4.	10′-Hydroxyusambarensine	10433813	448.56	3	3	4.40	142.46	0.55
5.	Strychnopentamine	6712640	549.75	3	4	4.68	180.14	0.55
6.	Remdesivir	121304016	602.58	4	12	1.50	150.43	0.17