Hybridization of Aminoadamantanes with Cinnamic Acid Analogues and Elucidation of Their Antioxidant Profile

Table 1

Synthesized N-cinnamoyl adamantane amides.

Substituted cinnamic acids		Amines	Products	Yields (%)
1a:	Cinnamic acid (CA)	3a	4a1: CA-Am	83
1b:	α-Methylcinnamic acid (α -CH3-CA)	3a	4a2:α-CH3-CA-Am	75
1c:	3-Methylcinnamic acid (CA (3-CH3))	3a	4a3: CA (3-CH3)-Am	70
1d:	4-Methylcinnamic acid (CA (4-CH3))	3a	4a4: CA (4-CH3)-Am	78
1e:	3,4-Diacetylcaffeic acid (CaffA (3,4-Ac2))	3a	4a5: CaffA (3,4-Ac2)-Am	65
1f:	Caffeic acid (CaffA)	3a	4a6: CaffA-Am	77
1g:	4-Hydroxycinnamic acid (CA (4-OH))	3a	4a7: CA (4-OH)-Am	42
1a:	CA	3b	4b1: CA-Mem	81
1f:	CaffA	3b	4b2: CaffA-Mem	54
1b:	α -CH3-CA	3b	4b3:α-CH3-CA-Mem	59
1c:	CA (3-CH3)	3b	4b4: CA (3-CH3)-Mem	55
1b:	α -CH3-CA	3c	4c1:α-CH3-CA-Rim	62
1h:	2-Methyl-cinnamic acid (CA (2-CH3))	3c	4c2: CA (2-CH3)-Rim	66
1c:	CA (3-CH3)	3c	4c3: CA (3-CH3)-Rim	71
1d:	CA (4-CH3)	3c	4c4: CA (4-CH3)-Rim	81
1e:	CaffA (3,4-Ac2)	3c	4c5: CaffA (3,4-Ac2)-Rim	51
1f:	CaffA	3c	4c6: CaffA-Rim	72